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North East Essex CCG
East Suffolk and North East Essex NHS Foundation Trust
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Notes:

Hospital only guidance

 Details...
08.01.05  Expand sub section  Other antineoplastic drugs
Axitinib (tabs)
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Link  NICE TA333: Axitinib for advanced renal cell carcinoma
   
Bosutinib (tabs)
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Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
Link  NICE TA576 Bosutinib for untreated chronic myeloid leukaemia (terminated appraisal)
   
Carfilzomib (injection)
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MHRA:Kyprolis▼- Reminder of risk of potentially fatal cardiac events

MHRA: Risk of reactivation of hepatitis B virus

 
Link  NICE TA457 : Carfilzomib for previously treated multiple myeloma
Link  NICE TA657 Carfilzomib for previously treated multiple myeloma
   
Cytotoxic Drug CemiplimabBlack Triangle
(IV infusion)
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BlueTeq
 
Link  NICE TA592 Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma
   
Ceritinib (caps)
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Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500 Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Dabrafenib (caps)
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Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544 Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
Cytotoxic Drug Dacomitinib (Vizimpro)
(Tablets)
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Link  NICE TA595 Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
   
Cytotoxic Drug DurvalumabBlack Triangle (Imfinzi)
(Solution for infusion)
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BlueTeq
 
Link  NICE TA578 Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation
Link  NICE TA662 Durvalumab in combination for untreated extensive-stage small-cell lung cancer (terminated appraisal)
   
Cytotoxic Drug EntrectinibBlack Triangle (Rozlytrek® 100mg and 200mg )
(hard capsules)
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Link  TA643: Entrectinib for treating ROS1-positive advanced non-small-cell lung cancer
Link  TA644 Enrectinib for treating NTRK fusion-positive solid tumours
   
Cytotoxic Drug Eribulin (injection)
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Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
Link  NICE TA515 Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen
   
Cytotoxic Drug Ibrutinib (caps)
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Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA502 Ibrutinib for treating relapsed or refractory mantle cell lymphoma
Link  NICE TA608 Ibrutinib with rituximab for treating Waldenstrom’s macroglobulinaemia (terminated appraisal)
   
Idelalisib (tabs)
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Link  NICE TA359: Chronic lymphocytic leukaemia - Idelalisib
   
Cytotoxic Drug Inotuzumab ozogamicin (Besponsa®)
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Link  TA 541 Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
   
Ixazomib (Ninlaro®)
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Link  NICE TA505 Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
   
Cytotoxic Drug LenvatinibBlack Triangle (Lenvima®)
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BlueTeq
 
Link  NICE TA498 Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
Link  NICE TA551 Lenvatinib for untreated advanced hepatocellular carcinoma
   
Cytotoxic Drug Panitumumab (Vectibix®)
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Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
   
Cytotoxic Drug Panobinostat (Farydak®)
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Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
   
Pembrolizumab (injection)
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Link  NICE TA357: Pembrolizumab for melanoma after ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA447 : Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  NICE TA519 Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA522 Pembrolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA531 Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  NICE TA540 Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA553 Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence
Link  NICE TA557 Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer
Link  NICE TA570 Pembrolizumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy (terminated appraisal)
Link  NICE TA600 Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
Link  NICE TA661 Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma
   
Ruxolitinib (tabs)
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Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Trametinib (tabs)
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Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544 Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
08.01.05  Expand sub section  Amsacrine
Cytotoxic Drug Amsacrine (injection)
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08.01.05  Expand sub section  Arsenic trioxide
Cytotoxic Drug Arsenic Trioxide (Trisenox 1mg/ml concentrate for infusion)
(injection)
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Link  NICE TA526 Arsenic trioxide for treating acute promyelocytic leukaemia
   
08.01.05  Expand sub section  Bevacizumab
Cytotoxic Drug Avelumab (injection)
(Oncology)
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BlueTeq
 
Link  https://www.nice.org.uk/guidance/ta517
Link  NICE TA645 Avelumab with axitinib for untreated advanced renal cell carcinoma
   
Bevacizumab (injection)
(Oncology)
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Link  Bevacizumab with carboplatin, gemcitabine and paclitaxel for treating the first recurrence of platinum-sensitive advanced ovarian cancer (terminated appraisal)
Link  NICE TA214: Breast Cancer with taxane
Link  NICE TA263: Breast cancer with capecitabine
Link  NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
   
Daratumumab (injection)
(Oncology)
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MHRA:Darzalex▼- Risk of reactivation of hepatitis B virus

 
Link  NICE TA510 Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
Link  NICE TA573 Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
   
Cytotoxic Drug Tivozanib (Capsules)
(Oncology)
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Link  NICE TA 512 Tivozanib for treating advanced renal cell carcinoma
   
08.01.05  Expand sub section  Bexarotene to top
08.01.05  Expand sub section  Bortezomib
Cytotoxic Drug Bortezomib (injection)
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Link  NICE TA 602 Pomalidomide with bortezomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)
Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: 1st line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
Link  NICE TA603 Lenalidomide with bortezomib and dexamethasone for untreated multiple myeloma (terminated appraisal)
   
08.01.05  Expand sub section  Brentuximab vedotin
Brentuximab vedotin (injection)
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Link  NICE TA446 : Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA524 Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA564 Brentuximab vedotin for untreated advanced Hodgkin lymphoma (terminated appraisal)
Link  NICE TA577 Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
Link  TA641 Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphoma
   
08.01.05  Expand sub section  Cetuximab
Cetuximab (Erbitux®)
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Link  NICE TA145: Head and neck cancer - cetuximab
Link  NICE TA176: Colorectal cancer (first line) - cetuximab
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473:Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
   
08.01.05  Expand sub section  Crisantaspase
Crisantaspase (Erwinase®)
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08.01.05  Expand sub section  Dacarbazine and Temozolomide to top
Cytotoxic Drug Dacarbazine (injection)
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Cytotoxic Drug Temozolomide (caps)
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Link  NICE TA121: Glioma (newly diagnosed and high grade)
Link  NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
   
08.01.05  Expand sub section  Erlotinib
Cytotoxic Drug MidostaurinBlack Triangle (Rydapt)
( Capsules)
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Link  NICE TA523 Midostaurin for untreated acute myeloid leukaemia
   
08.01.05  Expand sub section  Hydroxycarbamide
Cytotoxic Drug Hydroxycarbamide
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Traffic light information

Traffic light Details
Shared care Patients with myeloproliferative disorders needing cytoreduction
Red Oncology related indications
 
Link  SNEE ICS Hydroxycarbamide SCA (Adults) for use in myloproliferative disorders and sickle cell disease
   
08.01.05  Expand sub section  Imatinab
08.01.05  Expand sub section  Ipilimumab
Ipilimumab (injection)
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Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
   
08.01.05  Expand sub section  Mitotane to top
08.01.05  Expand sub section  Panitumumab
08.01.05  Expand sub section  Pentostatin
Cytotoxic Drug Pentostatin (injection)
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08.01.05  Expand sub section  Platinum compounds
Cytotoxic Drug Carboplatin
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Cytotoxic Drug Cisplatin (injection)
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Cytotoxic Drug Oxaliplatin
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Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
   
08.01.05  Expand sub section  Porfimer sodium and temoporfin
08.01.05  Expand sub section  Procarbazine to top
Cytotoxic Drug Procarbazine (caps)
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08.01.05  Expand sub section  Protein kinase inhibitors
Afatinib (tabs)
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Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
   
Cytotoxic Drug BrigatinibBlack Triangle (Alunbrig)
(Tablets)
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BlueTeq
 
Link  NICE TA571 Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
   
Cytotoxic Drug Cabozantinib (Cometriq®)
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Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516 Cabozantinib for treating medullary thyroid cancer
Link  NICE TA542 Cabozantinib for untreated advanced renal cell carcinoma
Link  NICE TA582 Cabozantinib for previously treated advanced hepatocellular carcinoma (terminated appraisal)
   
Crizotinib (caps)
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Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
Link  NICE TA529 Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
   
Dasatinib (tabs)
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Link  NICE TA241: CML where treatment with imatinib has failed
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Everolimus (Afinitor®)
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Link  NICE TA348: Preventing Rejection in Liver Transplant
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Cytotoxic Drug Gilteritinib (Xospata ®)
(40 mg film-coated tablets)
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Link  TA642 Gilteritinib for treating relapsed or refractory acute myeloid leukaemia
   
Cytotoxic Drug Imatinib (tabs, caps)
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Lapatinib
(tabs)
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Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
   
Nilotinib
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Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Dasatinib, nilotinib and imatinib for first line treatment of CML
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Pazopanib (tabs)
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Link  NICE TA215: Pazopanib in renal cell cancer
   
Cytotoxic Drug Regorafenib (tabs)
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Link  NICE TA514 Regorafenib for previously treated advanced hepatocellular carcinoma
Link  NICE TA555 Regorafenib for previously treated advanced hepatocellular carcinoma
   
Sorafenib (tabs)
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Sunitinib (caps)
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Link  NICE TA169: Renal cell carcinoma - sunitinib
Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Cytotoxic Drug Temsirolimus (injection)
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Cytotoxic Drug Vandetanib (tabs)
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See below for further information for educational material for the following areas

  • Serious risks for adults paedeatric patients
  • DOsing and monitoring guidance for paediatric patients

 

 
Link  NICE TA550 Vandetanib for treating medullary thyroid cancer
Link  Risk minimisation information for healthcare professionals
   
Vemurafenib (tabs)
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Link  NICE TA269: Vemurafenib for treating malignant melanoma
   
08.01.05  Expand sub section  Taxanes
Cytotoxic Drug Cabazitaxel (Jevtana®)
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Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
   
Cytotoxic Drug Docetaxel
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Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
Link  NICE TA109: Breast cancer (early) - docetaxel
   
Cytotoxic Drug Paclitaxel
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Link  NICE TA108: Breast cancer (early) - paclitaxel
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Paclitaxel - Albumin Bound Formulation (Abraxane®)
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Link  NICE TA360: Pancreatic cancer - paclitaxel with gemcitabine
   
08.01.05  Expand sub section  Topoisomerase I inhibitors
Cytotoxic Drug Irinotecan Hydrochloride (injection)
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MHRA:Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events

 
   
Cytotoxic Drug Topotecan (caps, injection)
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Link  NICE TA183: Cervical cancer (recurrent) - topotecan
Link  NICE TA184: Lung cancer (small-cell) - topotecan
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Trabectedin
Cytotoxic Drug Trabectedin (injection)
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Link  NICE TA185: Soft tissue sarcoma - trabectedin
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Trastuzumab to top
Cytotoxic Drug Pertuzumab (Perjeta®)
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Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  TA509 Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
   
Cytotoxic Drug Trastuzumab
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Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
Link  NICE TA34: Breast cancer - trastuzumab
Link  TA509 Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
   
Cytotoxic Drug Trastuzumab emtansine
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Link  NICE TA458 : Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxan
Link  TA632 Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancer
   
08.01.05  Expand sub section  Tretinoin
08.01.05  Expand sub section  Vismodegib
Cytotoxic Drug Niraparib  (caps)
(100mg)
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BlueTeq
 
Link  NICE TA528 Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
   
Cytotoxic Drug Vismodegib (caps)
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 ....
 Non Formulary Items
Cytotoxic Drug  Aflibercept  (Zaltrap®)

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Non Formulary
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Link  NICE TA307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
 
Alectinib  (Alecensa®)

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Non Formulary
 
Bexarotene  (Targretin®)

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Non Formulary
 
Carboplatin  (Paraplatin®)

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Non Formulary
 
Mitotane  (Lysodren®)

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Non Formulary
 
Necitumumab  (Portrazza®)

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Non Formulary
High Cost Medicine
Link  NICE TA411: Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer
 
Olaratumab

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MHRA: Withdrawal of the EU marketing authorisation due to lack of efficacy


Do not start new patients on olaratumab

For patients currently on treatment, consider alternative treatment options since available stock will expire by April 2020

Link  NOCE TA465: Olaratumab in combination with doxorubicin for treating advanced soft tissue sarcoma
 
Oxaliplatin  (Eloxatin®)

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Non Formulary
 
Pablociclib  (Ibrance®)

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Non Formulary
 
Paclitaxel  (Taxol®)

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Non Formulary
 
Ponatinib  (Iclusig®)

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Non Formulary
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MHRA: Reports of posterior reversible encephalopathy syndrome

Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
 
Porfimer Sodium  (Photofrin ®)

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Non Formulary
 
Ramucirumab  (Cyramza®)

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Non Formulary
High Cost Medicine
Link  NICE TA403: Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer
Link  NICE TA609 Ramucirumab for treating unresectable hepatocellular carcinoma after sorafenib (terminated appraisal)
 
Rociletinib

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Non Formulary
 
Sonidegib  (Odomzo®)

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Non Formulary
 
Cytotoxic Drug  Talimogene laherparepvec  (Imlygic®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
 
Temoporfin  (Foscan®)

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Non Formulary
 
Tretinoin  (Vesanoid®)

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Non Formulary
 
Vosaroxin  (Qinprezo)

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Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Blue

For routine prescribing in primary and secondary care.   

Green

Initiated (if clinically urgent) or advised (if non-urgent) by specialist in secondary care, prescribing can be continued in primary care.   

Amber

Shared care  

Red Hospital

Hospital only  

Double Red

There should be no prescribing of these drugs  

Mixed

The traffic light of the drug is dependant on the indication. Please see individual drug entry for details  

netFormulary