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North East Essex CCG
East Suffolk and North East Essex NHS Foundation Trust
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 Formulary Chapter 5: Infections - Full Chapter
Notes:

Primary care guidance

Antimicrobial formulary

Click here for Suffolk and North East Essex Primary care and A&E formulary 2020

 

Linezolid guidance

Linezolid should only be prescribed following a discussion with a consultant microbiologist. Please refer to the advice sheet (here) for information on monitoring and supply.

 

Hospital only guidance

Antimicrobial policy

Click here for Ipswich Hospital NHS Trust Antimicrobial policy (PDF)

Click here for Ipswich Hospital NHS Trust Antimicrobial policy app. This can be downloaded onto the hospital iPods and your personal phones/tablets.

Please note the PDF document this will only work if using a computer within the trust

Medication related guidelines

Management of Neutropenic Sepsis in Adult Cancer Patients Clinical Guideline

 Details...
05.01.07  Expand sub section  Some other antibacterials
05.01.07  Expand sub section  Rifaximin
Rifaximin (Targaxan®)
(Encephalopathy)
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Green

Reduction in recurrence of episodes of overt hepatic encephalopathy in patients ≥ 18 years of age

 
   
05.01.07  Expand sub section  Fidaxomicin
Fidaxomicin (Dificlir®)
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Formulary
Green

Traffic light information

Traffic light Details
Green

GreenTreatment of Clostridium difficile infections (CDI) also known as C. difficile associated diarrhoea (CDAD) in adults (third line after metronidazole and vancomycin; following a recommendation from a microbiologist- this may be verbal if patients are in the community)

 
   
05.03  Expand sub section  Antiviral drugs
05.03.01  Expand sub section  HIV infection to top
Atazanavir sulfate and cobicistat (Evotaz®)
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High Cost Medicine
NHS England
 
   
Cobicistat (Tybost®)
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High Cost Medicine
NHS England
 
   
Tenofovir alafenamide, elvitegravir, cobicistat & emtricitabine (Genvoya®)
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Formulary
High Cost Medicine
NHS England
 
   
05.03.01  Expand sub section  Nucleoside reverse transcriptase inhibitors
Abacavir (Ziagen®)
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Formulary
High Cost Medicine
NHS England

test

 
   
Abacavir and Lamivudine (Kivexa®)
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High Cost Medicine
NHS England
 
   
Abacavir and Lamivudine and Zidovudine (Trizivir®)
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Formulary
High Cost Medicine
NHS England
 
   
Didanosine (Videx®)
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Formulary
High Cost Medicine
NHS England
 
   
Emtricitabine (Emtriva®)
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Formulary
High Cost Medicine
NHS England
 
   
Emtricitabine + tenofovir alafenamide (Descovy®)
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Formulary
High Cost Medicine
NHS England
 
   
Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg (Eviplera®)
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High Cost Medicine
NHS England
 
   
Lamivudine (Epivir®)
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High Cost Medicine
NHS England

Indicated for HIV infection in combination with other antiretroviral drugs.  Also indicated for chronic hepatitis B infection.

 
   
Rilpivirine hydrochloride (Edurant®)
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High Cost Medicine
NHS England
 
   
Stavudine (Zerit®)
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High Cost Medicine
NHS England
 
   
Tenofovir 245mg, Efavirenz 600mg and Emtricitabine 200mg (Atripla®)
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Formulary
High Cost Medicine
NHS England
 
   
Tenofovir Disproxil (Viread®)
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Formulary

Indicated for HIV infection in combination with other antiretroviral drugs. Also indicated for chronic hepatitis B infection.

 
   
Tenofovir, cobicistat, elvitegravir & emtricitabine (Stribild®)
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High Cost Medicine
NHS England
 
   
Zidovudine (Retrovir®)
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Formulary
High Cost Medicine
NHS England
 
   
Zidovudine and lamivudine
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Formulary
High Cost Medicine
NHS England
 
   
05.03.01  Expand sub section  Protease inhibitors
Atazanavir (Reyataz®)
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Formulary
High Cost Medicine
NHS England
 
   
Darunavir (Prezista®)
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High Cost Medicine
NHS England

MHRA:Avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1

 
   
Darunavir and Cobicistat (Rezolsta®)
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Formulary
High Cost Medicine
NHS England

MHRA:Avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1

 
   
Fosamprenavir (Telzir®)
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Formulary
High Cost Medicine
NHS England
 
   
Indinavir (Crixivan®)
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Formulary
High Cost Medicine
NHS England
 
   
Lopinavir and Ritonavir (Kaletra®)
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Formulary
High Cost Medicine
NHS England
 
   
Nelfinavir (Viracept®)
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Formulary
High Cost Medicine
NHS England
 
   
Ritonavir (Norvir®)
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High Cost Medicine
NHS England

MHRA: Interaction with levothyroxine leading to reduced thyroxine levels

 
   
Saquinavir (Invirase®)
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Formulary
High Cost Medicine
NHS England
 
   
05.03.01  Expand sub section  Non-nucleoside reverse transcriptase inhibitors
Efavirenz (Sustiva®)
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Formulary
High Cost Medicine
NHS England
 
   
Nevirapine (Viramune®)
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High Cost Medicine
NHS England
 
   
05.03.01  Expand sub section  Other antiretrovirals
Dolutegravir
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High Cost Medicine
NHS England

MHRA:increased risk of neural tube defects; do not prescribe to women seeking to become pregnant; exclude pregnancy before initiation and advise use of effective contraception

 
   
Dolutegravir, abacavir & lamivudine (Triumeq®)
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High Cost Medicine
NHS England

MHRA:increased risk of neural tube defects; do not prescribe to women seeking to become pregnant; exclude pregnancy before initiation and advise use of effective contraception

 
   
Elvitegravir
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High Cost Medicine
NHS England
 
   
Enfuvirtide (Fuzeon®)
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Formulary
High Cost Medicine
NHS England
 
   
Maraviroc (Celsentri®)
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High Cost Medicine
NHS England
 
   
Raltegravir (Isentress ®)
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High Cost Medicine
NHS England
 
   
05.03.01  Expand sub section  Pharmacokinetic enhancers of anti-retrovirals to top
05.03.01  Expand sub section  Combination Products
05.03.02.02  Expand sub section  Cytomegalovirus infection
Ganciclovir
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Formulary
Red Hospital
High Cost Medicine
 
   
Valganciclovir
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Formulary
Red Hospital
High Cost Medicine
 
   
05.03.03  Expand sub section  Viral hepatitis
05.03.03.01  Expand sub section  Chronic hepatitis B
Adefovir Dipivoxil (Hepsera®)
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Restricted Drug Restricted
High Cost Medicine
NHS England

Not routinely commissioned by NHSE.  Needs IFR approval.

 
Link  NICE CG165: Hepatitis B (chronic) - incorporates TA96
Link  NICE TA96: Hep B - adefovir dipivoxil and pegylated interferon alpha-2a
   
Entecavir (Baraclude)
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High Cost Medicine
NHS England
 
Link  NICE CG165: Hepatitis B (incorporates TA153)
Link  NICE TA153: Hepatitis B (chronic) - etecavir
   
Lamivudine (Zeffix)
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High Cost Medicine
NHS England

Indicated for chronic hepatitis B infection. Also indicated for HIV infection in combination with other antiretroviral drugs.

 
Link  NICE TA165 Hepatitis B (chronic): diagnosis and management
   
Tenofovir disoproxil (Viread)
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High Cost Medicine
NHS England

Indicated for chronic hepatitis B infection. Also indicated for HIV infection in combination with other antiretroviral drugs

 
Link  NICE TA173 Tenofovir disoproxil for the treatment of chronic hepatitis B
   
05.03.03.02  Expand sub section  Chronic hepatitis C to top
 note 

MHRA:Direct-acting antivirals for chronic hepatitis C: risk of hypoglycaemia in patients with diabetes

Boceprevir (Victrelis®)
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High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA253: hepatitis
   
Daclatasvir  (Daklinza®)
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High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA364: Daclatasvir for treating chronic hepatitis C
   
Dasabuvir (Exviera®)
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High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Elbasvir/Grazoprevir (Zepatier®)
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High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
   
Ledipasvir and Sofosbuvir (Harvoni®)
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Formulary
High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TAG63: Ledipasvir–sofosbuvir for treating chronic hepatitis C
Link  NICE TA430 : Sofosbuvir–velpatasvir for treating chronic hepatitis C
   
Ombitasvir/ paritaprevir/ ritonavir (Viekirax®)
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Formulary
High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Simeprevir (Olysio®)
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Formulary
High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA331: Simeprevir with peginterferon alfa & ribavirin for hepatitis C
   
Sofosbuvir (Sovaldi®)
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High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
   
Sofosbuvir/velpatasvir/voxilaprevirBlack Triangle (Vosevi)
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Formulary
High Cost Medicine
NHS England
BlueTeq
 
Link  Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
   
Telaprevir (Incivo®)
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Formulary
High Cost Medicine
NHS England
BlueTeq
 
Link  NICE TA252: Telaprevir in hepatitis C
   
05.06  Expand sub section  MISC
 ....
 Non Formulary Items
Amprenavir  (Agenerase®)

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Non Formulary
 
Cidofovir infusion  (Vistide®)

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Non Formulary
High Cost Medicine
 
Dalbavancin

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Non Formulary
 
Emtricitabine + tenofovir alafenamide  (Descovy®)

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Non Formulary
 
Emtricitabine + tenofovir alafenamide  (Descovy®)

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Non Formulary
 
Etravirine  (Intelence®)

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Non Formulary
High Cost Medicine
 
Foscarnet Sodium  (Foscavir®)

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Non Formulary
High Cost Medicine
 
Lamivudine & raltegravir  (Dutrebis®)

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Non Formulary
High Cost Medicine
 
Oritavancin  (Orbactiv®)

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Non Formulary
 
Rifaximin  (Xifaxanta®)
(C.Diff and SIBO)

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Non Formulary
 
Rilpiverine, emtrictabine and tenofovir alafenamide

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Non Formulary
 
Sinecatechins  (Veregen)

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Non Formulary
 
Tedizolid  (Sivextro®)

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Non Formulary
 
Tenofovir and Emtricitabine  (Truvada®)

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Non Formulary
High Cost Medicine
 
Tipranavir  (Aptivus®)

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Non Formulary
High Cost Medicine
 
Zidovudine and Lamivudine  (Combivir®)

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Blue

For routine prescribing in primary and secondary care.   

Green

Initiated (if clinically urgent) or advised (if non-urgent) by specialist in secondary care, prescribing can be continued in primary care.   

Amber

Shared care  

Red Hospital

Hospital only  

Double Red

There should be no prescribing of these drugs  

Mixed

The traffic light of the drug is dependant on the indication. Please see individual drug entry for details  

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