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 Formulary Chapter 20: Unlicensed Medicines / Significant off-label use - Full Chapter
Notes:

Hospital only guidance

Prescribing guidance

These medicines do not have a license for use in the United Kingdom.

Unlicensed medicines are only available on a named patient basis on the signature of a consultant.

Some medicines may only be used in accordance with a trust protocol

 Details...
20  Expand sub section  Unlicensed Medicines
5 Mop (Methoxypsoralen)  (20mg tabs)
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Formulary
Red Hospital
 
   
8 Mop (Methoxypsoralen)
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Formulary
Red Hospital

Available as 

  • bath lotion 1.2%
  • emulsion 0.15%
  • 10mg tablets
 
   
Albendazole 400mg tablets
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Formulary
Red Hospital
 
   
Cytotoxic Drug ALTRETAMINE (HEXAMETHYLMELAMINE) Capsules 50 mg
Formulary
Red Hospital
 
   
ALUMINIUM ACETATE 13% ear drops
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Formulary
Red Hospital
 
   
Benzbromarone 50mg
Formulary
Red Hospital
 
   
Biotin (Vitamin H)  (5mg tablets)
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Formulary
Red Hospital
 
   
C1esterase inhibitor
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Formulary
Red Hospital
 
   
Caffeine oral solution (5mg in 1ml)
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Formulary
Red Hospital

Low CSF pressure headache

 
   
Caffeine Sodium Benzoate Injection
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Formulary
Red Hospital

Low CSF pressure headache

 
   
Calcitriol 1mcg in 1ml oral solution
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Formulary
Red Hospital
 
   
CAPTOPRIL Oral Solution 5 mg in 1mL
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Formulary
Red Hospital
 
   
Chloral hydrate suppositories
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Formulary
Red Hospital
 
   
Chlorothiazide 250mg in 5mls suspension
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Formulary
Red Hospital
 
   
Colecalciferol injection  (300,000 units in 1ml)
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Formulary
Red Hospital
 
   
Desmopressin (high strength)  (15mcg in 1ml)
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Formulary
Red Hospital
 
   
DIAZOXIDE Suspension 50 mg in 1mL
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Formulary
Red Hospital
 
   
Disodium edetate EDTA 0.37% drops
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Formulary
Red Hospital

Available as 

  • eye drops
  • preservative free eye drops
 
   
Edrophonium 10mg/ml injection
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Formulary
Red Hospital
 
   
Ergocalciferol 20,000 units in 1ml oral solution
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Formulary
Red Hospital
 
   
Ethinylestradiol 2mcg tabs
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Formulary
Red Hospital
 
   
Flucytosine 500mg tablets
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Formulary
Red Hospital
 
   
Fluorescein 20% 5ml amps
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Formulary
Red Hospital
 
   
Fumaric acid (Fumaderm) tablets
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Formulary
Red Hospital

Consultant dermatologists only for use in psoriasis

 
   
GEMTUZUMAB - OZOGAMICIN Injection 5 mg
Formulary
Red Hospital
 
Link  NICE TA545 Gemtuzumab ozogamicin for untreated acute myeloid leukaemia
   
Gentamicin 0.1% cream
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Formulary
Red Hospital

Prophylaxis for exit site infections in CAPD pts allergic to mupirocin

 
   
Glycerol Injection
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Formulary
Red Hospital

Pain formulary only

 
   
Gonadorelin (relefact) 100mcg injection
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Formulary
Red Hospital
 
   
Iloprost
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Formulary
Red Hospital

Available as

  • 100mcg in 1ml
  • 50mcg in 0.5ml
 
   
IOPANOIC ACID Tablets 500 mg
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Formulary
Red Hospital

For endocrinology team use only

 
   
Isoniazid 50mg / 5ml oral solution
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Formulary
Red Hospital
 
   
LEVAMISOLE Tablets 50 mg
Formulary
Red Hospital
 
   
Magnesium glycerophosphate liquid
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Formulary
Red Hospital
 
   
Mepacrine 100mg
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Formulary
Red Hospital
 
   
Mercaptopurine 10mg tablets
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Formulary
Red Hospital
 
   
Metaraminol 10mg in 1ml injection
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Formulary
Red Hospital
 
   
MIDAZOLAM buccal
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Formulary
Red Hospital
 
   
Mydricaine No. 2 injection
Formulary
Red Hospital
 
   
PAPAVERINE 60mg in 1ml injection
Formulary
Red Hospital

Available for accidental injection of thiopentone

 
   
Paraldehyde / olive oil 50/50 Enema
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Formulary
Red Hospital
 
   
Patent blue V 2.5% solution
Formulary
Red Hospital
 
   
Phenylbutazone 100mg
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Formulary
Red Hospital
 
   
Phytomenadione (Konakion®) 10mg capsules/tablets
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Formulary
Blue

Preparation should only be used if licensed Vitamin K is not available 

Please note prices between tablets and capsules may vary and the formulation with the lowest acquisition cost should be used  

 
   
Polyhexyethylene (Polihexanide) Biguanide 0.05% Eye drops
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Formulary
Red Hospital
 
   
Praziquantel 500mg tablets
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Formulary
Red Hospital
 
   
Probenecid 500mg tablets
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Formulary
Red Hospital
 
   
Pyrazinamide tablets 500mg
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Formulary
Red Hospital
 
   
PYRIDOXAL PHOSPHATE Tablets 50 mg
Formulary
Red Hospital
 
   
Riboflavin (Vitamin B2) tablets 200mg
Formulary
Red Hospital
 
   
Sodium benzoate
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Formulary
Red Hospital

Available as

  • 500g in 5ml liquid
  • 500mg tablets
  • IV 2g in 10ml
 
   
Sodium chloride 5% eye oint
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Formulary
Red Hospital
 
   
Sodium phenylbutyrate
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Formulary
Red Hospital

Available as 

  • tablets - 500mg
  • powder - 250mg in 1ml
  • injection - 2g in 10ml
 
   
SPIRONOLACTONE Liquid
Formulary
Green

Available as

  • 25mg in 5ml
  • 50mg in 5ml
 
   
TALC BP purified sterile
Formulary
Red Hospital

Hospital only guidance

Prescribing guidance

Talc for Pleurodesis

 
   
Terracortril (Oxytetracycline + Hydrocortisone)
View adult BNF View SPC online View childrens BNF
Formulary
Red Hospital
Overgranulation 
   
Tham injection 7%
Formulary
Red Hospital
 
   
THIAMINE Injection 100 mg in 1mL
Formulary
Red Hospital
 
   
 ....
 Non Formulary Items


View adult BNF View SPC online View childrens BNF
Non Formulary
Red Hospital
 
PENTOSAN POLYSULPHATE Capsules 50 mg  (Elmiron® )

Non Formulary

MHRA: Rare risk of pigmentary maculopathy

 
SODIUM CHLORIDE Solution 7 % Nebules  (Nebusal® - see section3 now)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Blue

For routine prescribing in primary and secondary care.   

Green

Initiated (if clinically urgent) or advised (if non-urgent) by specialist in secondary care, prescribing can be continued in primary care.   

Amber

Shared care  

Red Hospital

Hospital only  

Double Red

There should be no prescribing of these drugs  

Mixed

The traffic light of the drug is dependant on the indication. Please see individual drug entry for details  

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